Technical aspects of an impact acceleration traumatic brain injury rat model with potential suitability for both microdialysis and PtiO2 monitoring. - SSA - Service de santé des armées Accéder directement au contenu
Article Dans Une Revue Journal of Neuroscience Methods Année : 2004

Technical aspects of an impact acceleration traumatic brain injury rat model with potential suitability for both microdialysis and PtiO2 monitoring.

Emmanuel Cantais
  • Fonction : Auteur
Olivier Darbin
  • Fonction : Auteur
Jean-Pierre Terrier
  • Fonction : Auteur
Michel Lonjon
  • Fonction : Auteur
Bruno Palmier
  • Fonction : Auteur
Jean-Jacques Risso
  • Fonction : Auteur

Résumé

This report describes technical adaptations of a traumatic brain injury (TBI) model-largely inspired by Marmarou-in order to monitor microdialysis data and PtiO2 (brain tissue oxygen) before, during and after injury. We particularly focalize on our model requirements which allows us to re-create some drastic pathological characteristics experienced by severely head-injured patients: impact on a closed skull, no ventilation immediately after impact, presence of diffuse axonal injuries and secondary brain insults from systemic origin...We notably give priority to minimize anaesthesia duration in order to tend to banish any neuroprotection. Our new model will henceforth allow a better understanding of neurochemical and biochemical alterations resulting from traumatic brain injury, using microdialysis and PtiO2 techniques already monitored in our Intensive Care Unit. Studies on efficiency and therapeutic window of neuroprotective pharmacological molecules are now conceivable to ameliorate severe head-injury treatment.
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Dates et versions

ssa-00165574 , version 1 (26-07-2007)

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Emilie Carré, Emmanuel Cantais, Olivier Darbin, Jean-Pierre Terrier, Michel Lonjon, et al.. Technical aspects of an impact acceleration traumatic brain injury rat model with potential suitability for both microdialysis and PtiO2 monitoring.. Journal of Neuroscience Methods, 2004, 140 (1-2), pp.23-8. ⟨10.1016/j.jneumeth.2004.04.037⟩. ⟨ssa-00165574⟩

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